Vyrelady

Vyreladies are found during the quest The Branches of Darkmeyer in the high tier area within Darkmeyer. They're aggressive unless all four parts of the Darkmeyer disguise are equipped. If the player does not have the full Darkmeyer disguise equipped, they will become permanently aggressive.

They are the female version of the Vyrelord.

Fighting them
Vyreladies can be fought with any armour; however, they are completely impervious to most weapons and poisons. They can only be poisoned with a Dreadnip, but otherwise they are only vulnerable to the ivandis flail and blisterwood weapons.

The corpses these drop can be cremated in the Paterdomus Columbarium. Cremating 500 corpses is a requirement for the Completionist Cape (t), as well as making the Blisterwood weapons and Flail more effective, increase the ease at which to kill them.

The best method to kill these would be to use the altar located west of the bank which allows you to use all your prayers whilst they aggressively swarm towards you and to recharge your prayer points easily.

Melee
They are good for training due to the increased hits provided by the use of blisterwood weapons, all of which hit very high on them. The polearm is notably effective, and can easily hit over 800 with sufficient bonuses, like using Turmoil and an Extreme set. An ivandis flail may also be used, but this is not advised due to the flail's slightly lower stats and slower attack speed compared to the polearm. The only reason could be the special effect, but once blisterwood weapons are 'unlocked' even that is less useful.

Magic
With blisterwood weapons mastered (500 corpses burnt), using magic to train either magic or defence has a tendency of giving one of the best experience rates in the game. Abilities such as asphyxiate will kill vyres extremely quickly, granting fast experience. You can constantly hit over 1000 against vyres, using magic. This gives upwards of to 250k magic or defence experience per hour, variant upon which experience you have chosen to train.

Ranged
Especially with blisterwood weapons mastered (500 corpses burnt), using blisterwood stakes and extreme ranging potions to kill the Vyreladies is extremely easy; giving upwards of 120k ranged experience per hour. The ease is increased with easy access to an altar, one can stay here for a very long time by using protect from/deflect magic prayer and with little attention as the Vyreladies are aggressive when not wearing the Darkmeyer disguise.